An updated review of the scientific literature on the origin of SARS-CoV-2Review Published on 2022-12-012023-07-10 Journal: Environmental research [Category] COVID19(2023년), [키워드] COVID-19 hosts Laboratory leak SARS-CoV-2 zoonotic origin. [DOI] 10.1016/j.envres.2022.114131 PMC 바로가기 [Article Type] Review
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived VariantsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 Basis binding binding affinity binding mechanism changes in complexes coronavirus Cross-species transmission cryo-EM cryo-EM structure demonstrated examined expressing F486L facilitate highlight hosts Human human cell human monoclonal antibodies humans identify indicated Infection information Interaction mechanism Microscopy mink molecular mechanism Mutation N501T neutralized prevented Protein pseudovirus RBD RBD variant RBD variants receptor reduced residue SARS-CoV-2 SARS-CoV-2 variant sera Structure the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 transmitted variant variants virus entry Virus entry. viruses Y453F [DOI] 10.1128/jvi.00814-22 PMC 바로가기
Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With MyelomaArticle Published on 2022-09-102022-11-15 Journal: Journal of clinical oncology : official journal of [Category] SARS, 변종, 진단, 치료기술, [키워드] affected analyzed antibody B-cell malignancy BNT162b2 Booster vaccine Characteristics Critical Delta detect detectable determinant disease environmental exposure Factors greater hosts Immunocompromised implication increased risk induction initial lack Live virus Moderna MONITOR Mortality mRNA1273 much lower Multiple myeloma Myeloma NAb neutralization neutralize neutralizing antibody neutralizing capacity nucleocapsid Patient patients Pseudovirus neutralization assay quantified RBD receiving response SARS CoV-2 Seroconversion Serologic response significantly spike receptor-binding domain the vaccine Treatment vaccination Vaccine vaccine-induced antibody variant viral neutralization virus virus-neutralizing were measured [DOI] 10.1200/JCO.21.02257 PMC 바로가기
Two Years into the COVID-19 Pandemic: Lessons LearnedArticle Published on 2022-09-092022-11-16 Journal: ACS Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome caused Clinical features clinical manifestations coronavirus coronavirus disease Coronaviruses COVID-19 Diagnosis disease Epidemiology etiology global public health highlighting highly pathogenic hosts impacted IMPROVE knowledge lesson management pathophysiology prevention public health authority reservoir hosts Respiratory disease SARS-CoV-2 selected Topic Transmission Treatment Vaccines variants variants. virulent virus widespread Wuhan, China Year [DOI] 10.1021/acsinfecdis.2c00204 PMC 바로가기
Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccineArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] all age group animal models Antigen approach Asymptomatic Attenuated benefit catch caused center Characteristics common cold Control did not reduce drug effective effort Engineering Express healthy Hospitalization hosts Human Human rhinovirus immune response Immunity induce Infection intranasal intranasal vaccination live vaccine Mortality mucosal nasal swab pandemic coronavirus pathogen pathogenic prevention Protective Proteins reducing Replication replication competent respiratory virus rhinovirus rhinovirus Rhinovirus. rhinoviruses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 serotype serum Social distancing measure Spread strain tested Vaccine vaccine candidate vector virus [DOI] 10.3389/fimmu.2022.871463 PMC 바로가기
A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article